Progress in the regulation of glucagon secretion in intra islets
10.3969/j.issn.1006-6187.2018.03.015
- VernacularTitle:胰岛局部胰升血糖素分泌调节的研究进展
- Author:
Ke LI
1
;
Wenjing SONG
;
Jiaqing SHAO
Author Information
1. 南方医科大学南京临床学院内分泌科
- Keywords:
Glucagon;
Paracrine regulation;
Intrinsic regulation;
Juxtacrine regulation;
Sodium-glucose cotransporter regulation
- From:
Chinese Journal of Diabetes
2018;26(3):253-256
- CountryChina
- Language:Chinese
-
Abstract:
In addition to the impaired insulin secretion,the dysregulation of hyperglycermic hormone glucagon also takes part in the development and progress of diabetes,exacerbating the diabetic metabolic outcome.Although there has been a significant breakthrough in the current research on the regulation of insulin secretion,relatively little research on the roleof glucagon has been carried out.Actually,except for the paracrine regulation on glucagon secretion,pancreatic α-cell has also been proposed to be regulated by intrinsic mechanism,juxtacrine-mediated and sodium-glucose cotransporter.Furthermore,some factors outside the islet also affect on the glucagon secretion.Thus,more research on the complex secretory regulation of glucagon will provide a theoretical basis for our further understanding of the development of diabetes.In this review,we will summary the progress in the regulation of glucagon secretion in intra islets.
