Current situation and research progress of BMSCs transplantation in the treatment of diabetes mellitus and diabetes complications

VernacularTitle:骨髓间充质干细胞移植治疗糖尿病及其并发症的现状及研究进展
Author: Ranran LI ¹ ; Yabin CHEN ; Shundong CANG
Author Information

1. 450003,郑州大学人民医院肿瘤内科
Keywords: Bone marrow mesenchymal stem cells; Diabetes mellitus; Diabetes complications
From: Chinese Journal of Diabetes 2018;26(2):166-169
CountryChina
Language:Chinese
Abstract: Bone marrow mesenchymal stem cells (BMSCs) have a strong self-renewal ability and multi-directional differentiation potential, so they are ideal cells for cell transplantation, and are widely used in the treatment of diabetes, osteoarthritis and other diseases. BMSCs could increase insulin and C peptide levels in patients by a variety of mechanisms, and a good blood glucose control could be achieved without exogenous insulin therapy. Recently, a number of clinical studies confirmed the safety and effectiveness of BMSCs transplantation in the treatment of diabetes. BMSCs transplantation has also achieved good results for treating complications of diabetes, such as diabetic nephropathy, diabetic peripheral vascular disease, diabetic cardiomyopathy, diabetic bone disease and others. However, due to the lack of standardized transplantation regimens, BMSCs transplantation has been limited in the clinical application. This review summarized the status and research progress of BMSCs transplantation in the treatment of diabetes mellitus and its complications.