Research progress of the association between Hp polymorphism and diabetic vascular complications
10.3969/j.issn.1006-6187.2017.11.018
- VernacularTitle:结合珠蛋白基因多态性与糖尿病血管并发症的研究进展
- Author:
Yangyang WANG
1
;
Bin YI
Author Information
1. 中南大学湘雅三医院
- Keywords:
Haptoglobin;
Gene polymorphism;
Diabetes mellitus;
Complications
- From:
Chinese Journal of Diabetes
2017;25(11):1046-1050
- CountryChina
- Language:Chinese
-
Abstract:
Haptoglobin (Hp),also known as hemopexin,is an acute phase protein expressed predominantly in the liver.Hp binds to free Hemoglobin (Hb),and this Ht-Hb complex is degraded via CD163 (macrophage scavenger receptor)-mediated endocytosis,which subsequently blocks Hb-induced oxidative damage.There are three major human Hp genotypes:HP1-1,HP2-1,and HP2-2.Studies have shown that different HP genotype has distinct impact on diabetic vascular complications.In this review,we focus on the association between HP polymorphisms and diabetic vascular complications.
