Research progress on animal models of Parkinson's disease
10.3969/j.issn.1671-7856.2018.05.005
- VernacularTitle:帕金森疾病动物模型的研究进展
- Author:
Zhicheng ZHANG
1
;
Yuan YUAN
;
Xuan WANG
;
Qingkai SONG
;
Jiejie DAI
Author Information
1. 昆明医科大学
- Keywords:
Parkinson' s disease;
PD;
6-hydroxydopamine;
6-OHDA;
1-methyl-4-phenyl-1;
2;
3;
6-tetrahydropyridine;
MPTP;
neurotoxins;
transgenic;
animal models
- From:
Chinese Journal of Comparative Medicine
2018;28(5):21-27
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a progressive neurodegenerative disorder, with an etiology that is now considered to be due to interaction between genetic and environmental factors. Typical PD features include loss of dopaminergic neurons in the nigrostriatal region, with typical motor traits of PD associated with dopamine deficiency. Animal models have contributed to determining PD etiology and pathogenesis,as well as testing new therapeutic schedules and novel drug research. Rodents, tree shrews, primates, and other animal models of PD have been established by different method. These models each have their own advantages and limitations, showing different clinical features and pathological mechanisms to those in humans. Therefore, the appropriate model for scientific research must be carefully considered. This article reviews the main neurotoxic and transgenic models of PD.
