Research progress of focal ischemic stroke in nonhuman primates using endovascular methods
10.3969/j.issn.1671-7856.2018.05.004
- VernacularTitle:血管内介入方法制备非人灵长类动物局部脑缺血模型的研究进展
- Author:
Di WU
1
;
Xiaoduo HE
;
Jian CHEN
;
Yuchuan DING
Author Information
1. 首都医科大学宣武医院中美神经科学研究所
- Keywords:
stroke;
animal models;
nonhuman primates;
NHPs
- From:
Chinese Journal of Comparative Medicine
2018;28(5):16-20
- CountryChina
- Language:Chinese
-
Abstract:
The Stroke Therapy Academic Industry Roundtable(STAIR)committee has suggested that nonhuman primates(NHPs)should be used for preclinical stroke studies owing to previous translational failures. Ischemia induced by endovascular method closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This method also shows potential for endovascular treatment. This review provides a detailed summary of NHP models using endovascular method,including advantages and disadvantages,and potential applications. Additionally,we also provide further analysis based on different kinds of emboli,infract size,and abnormal hemodynamics. Selection of the optimum model will pave the way for translational research.
