The structure of histone deacetylase 2 and its role in diseases
10.3969/j.issn.1671-7856.2018.04.021
- VernacularTitle:组蛋白去乙酰酶2的结构及其在疾病中的作用
- Author:
Xin SUN
1
;
Deming ZHAO
;
Lifeng YANG
;
Xiangmei ZHOU
Author Information
1. 中国农业大学动物医学院国家动物海绵状脑病实验室
- Keywords:
histone deacetylase 2;
deacetylation;
histone;
transcriptional inhibition
- From:
Chinese Journal of Comparative Medicine
2018;28(4):116-119,112
- CountryChina
- Language:Chinese
-
Abstract:
Histone acetylation is one of the most important reactions of post-translational modification of histones, which plays an important role in the regulation of epigenetic processes. Histone deacetylase 2 as a member of type I histone deacetylases,involved in the catalytic regulation of histone and a variety of non-histone deacetylation,regulates a variety of life processes. This paper summarizes the basic structure of histone deacetylase 2 and the role of histone deacetylase 2 in various diseases,and provides a theoretical basis for conducting related studies.
