Establishment of basic data of Bama minipigs for embryo-fetal development toxicity study
10.3969/j.issn.1671-7856.2018.04.014
- VernacularTitle:巴马小型猪胚胎-胎仔发育毒性试验基础数据的建立
- Author:
Yuanhui ZHANG
1
;
Xinyan HAO
;
Hong GAO
Author Information
1. 中国医学科学院医学实验动物研究所
- Keywords:
Bama minipig;
embryonic development;
reproductive toxicity study
- From:
Chinese Journal of Comparative Medicine
2018;28(4):81-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obtain the basic data of Bama minipigs and provide basic reference for embryo-fetal developmental toxicity study. Methods Pregnant minipigs were sacrificed at different days during the gestation period respectively. The examinations included necropsy,count of corporea lutea,live and dead implantations,fetal body weight, and external,visceral, and skeletal examination of fetuses. Results The basic data of Bama minipigs, such as body weight, fetal development, and fetal malformation/variation were obtained. Conclusions We obtained the basic reproductive parameters of pregnant Bama minipigs and the indexes of fetal development, which can provide valuable reference data for embryo-fetal developmental toxicity tests of Bama minipigs.
