Determination and comparison of the bone mineral density of different skeletal regions of female Wistar rats at different ages
10.3969/j.issn.1671-7856.2018.04.011
- VernacularTitle:不同年龄段雌性Wistar大鼠不同骨骼区域骨密度值的测定与比较
- Author:
Yousong YE
1
;
Chenyun WANG
;
Zheli LI
;
Kaili MA
;
Donghong TANG
Author Information
1. 中国医学科学院/北京协和医学院医学生物学研究所
- Keywords:
Wistar rats;
bone area;
BMD
- From:
Chinese Journal of Comparative Medicine
2018;28(4):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide reference values for bone mineral density(BMD)in different skeletal regions of female Wistar rats at different ages. Methods Thirty SPF female Wistar rats were selected. The BMD of different skeletal regions(skull,upper limbs,thighs,trunk,ribs,pelvis,spine and the whole body)was measured by dual energy X-ray absorptiometry(DXA)at 6,10,12,24 and 30 months of age. The bone mineral densities between different age groups and that of different skeletal regions in the same age groups were compared. Results The BMD of the skull,upper limbs,thighs,trunk,ribs,pelvis, spine and the whole body was increased rapidly with age, and reached a peak at 10 months of age. The BMD of the skull,upper limbs,thighs,trunk,ribs were significantly higher than the whole body BMD in the same month-age group(P< 0.05 or P< 0.01). However,there was no significant difference between the pelvic, spine and the whole body BMD(P> 0.05). There was a significant positive correlation among the three correlations(P<0.01). Conclusions Some background data are provided for the bone biology studies of female Wistar rats, and provide useful supplementary reference for the studies of bone metabolism in rats and their application in biomedicine.
