Inhibitory effect of atrial natriuretic peptide(ANP)on the tumor growth of ANP knockout mouse and C57BL/6J mouse models of subcutaneous xenotransplanted melanoma
10.3969/j.issn.1671-7856.2018.04.003
- VernacularTitle:心房钠尿肽对基因敲除小鼠移植黑色素瘤生长的抑制作用
- Author:
Cuiling QI
1
;
Jinghua CAO
;
Yajun HE
;
Mengshi LI
;
Qianming LI
;
Yang YANG
;
Lijing WANG
Author Information
1. 广东药科大学
- Keywords:
atrial natriuretic peptide;
ANP;
ANP knockout mice;
melanoma;
proliferation;
angiogenesis
- From:
Chinese Journal of Comparative Medicine
2018;28(4):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of atrial natriuretic peptide(ANP)deletion on melanoma growth. Methods A subcutaneous xenotransplanted melanoma model was established in ANP knockout mice and C57BL/6J mice. The tumor volume was measured at the sixth day after establishment of the subcutaneous transplantation. Tumor cell proliferation and tumor-induced angiogenesis were detected by immunohistochemical staining. Results The volume and weight of xenotransplanted melanoma were significantly decreased in the ANP knockout mice compared with those in the C57BL/6J mice. The proliferative tumor cells and microvessel density were significantly decreased in the tumor tissues of ANP knockout mice compared with those in the C57BL/6J mice. Conclusions ANP deletion significantly suppresses xenotransplanted melanoma growth through inhibiting the tumor cell proliferation and angiogenesis.
