Research progress on the effects of assisted reproductive technology on phenotypes of mice
10.3969/j.issn.1671-7856.2018.03.022
- VernacularTitle:辅助生殖技术对小鼠表型影响的研究进展
- Author:
Yongyan HU
1
;
Shenshen KONG
Author Information
1. 北京大学第一医院实验动物中心
- Keywords:
assisted reproductive technology;
ART;
phenotypes;
mice
- From:
Chinese Journal of Comparative Medicine
2018;28(3):114-118
- CountryChina
- Language:Chinese
-
Abstract:
The offspring generated by assisted reproductive technology(ART)are considered genetically identical with those generated by natural fertilization. However,studies have found that there are differences between them in some phenotypes to varying extents. In this review, we have summarized the effects of ART on the sex ratio, growth and development,behavior,life expectancy, metabolism of organs and tissues, and molecular phenotypes of mice, providing some guidance to the problems that may arise during the application of ART in the production of genetically modified mice, rapid propagation,purification,embryo cryopreservation,and so on.
