Research progress on molecular mechanisms of angiogenesis after acute myocardial infarction
10.3969/j.issn.1671-7856.2018.03.021
- VernacularTitle:急性心肌梗死后血管新生相关分子机制的研究进展
- Author:
Jiamin CUI
1
;
Tingting LIU
;
Fangling SUN
;
Deyu GUO
;
Wen WANG
;
Jingshan SHI
Author Information
1. 遵义医学院基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室
- Keywords:
myocardial ischemia;
angiogenesis;
pro-angiogenic factors;
polypeptide growth factors;
acute myocardial infarction
- From:
Chinese Journal of Comparative Medicine
2018;28(3):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is a process that new blood vessels generate on the basis of an original vascular plexus via sprouting or other forms during normal growth and development of an organism or under particular conditions such as wound repairing and ischemic hypoxia. In general, angiogenesis includes five stages: degradation of the vascular basement membrane, endothelial cell proliferation, vascular sprouting, lumen formation and vascular network turning stable and mature. Among ischemic heart diseases, acute myocardial infarction seriously threatens human health, its pathological characteristics include myocardial vascular stenosis and blockage,leading to myocardial infarction. Therefore,the promotion of angiogenesis has become one of the therapies for ischemic heart diseases. A variety of pro-angiogenic cytokines are involved in the process of angiogenesis, such as polypeptide growth factors and lipid mediators. In this paper we review the recent progress in research on the expression of pro-angiogenic factors in myocardium after ischemic myocardial infarction.
