Application of near-infrared fluorescent dyes in tumor diagnosis
10.3969/j.issn.1671-7856.2018.03.019
- VernacularTitle:近红外荧光(NIRF)染料在肿瘤诊断中的应用
- Author:
Yong ZHAO
1
;
Hao WANG
;
Changhong SHI
Author Information
1. 第四军医大学实验动物中心
- Keywords:
near-infrared fluorescent dye;
NIRF dye;
tumors;
diagnosis;
nano-modifications;
multimodal imaging
- From:
Chinese Journal of Comparative Medicine
2018;28(3):98-102
- CountryChina
- Language:Chinese
-
Abstract:
Optical molecular imaging is more and more widely used in the field of biomedical sciences due to its advantageous properties such as non-invasive, real-time and high resolution. As a kind of important optical molecular imaging probe,the near-infrared fluorescent(NIRF)dyes exhibit less tissue absorption and strong tissue penetration,and has been gradually applied to the early diagnosis of tumors. Researchers have developed a number of NIRF dyes with high potential for clinical application by conjugating tumor-targeting ligands,nano-modifications and multimodal NIRF imaging, and have significantly improved the specificity and sensitivity of these NIRF dyes in tumor diagnosis. In this paper we provide a review on the application of NIRF dyes in tumor diagnosis.
