Interaction between autophagy and apoptosis during tumor development
10.3969.j.issn.1671-7856.2018.02.019
- VernacularTitle:肿瘤发展过程中自噬与凋亡的相互作用
- Author:
Yueyi KAN
1
;
Yajie WANG
;
Qi LI
;
Yujie LI
;
Qing YANG
;
Xiaogang WENG
;
Ying CHEN
;
Weiyan CAI
;
Xiaoxin ZHU
Author Information
1. 安徽中医药大学
- Keywords:
autophagy;
apoptosis;
proteins;
Beclin1;
P53;
reactive oxygen species;
tumor progression
- From:
Chinese Journal of Comparative Medicine
2018;28(2):106-112
- CountryChina
- Language:Chinese
-
Abstract:
The proliferation of tumor cells is regulated by a complex array of signaling pathways, among these signaling pathways,the programmed cell death. Autophagy and apoptosis are two types of programmed death. There are significant differences in their morphological and functional features, but they also have many links. Both apoptosis and autophagy are involved in activation,expression and regulation of a series of genes. By reviewing the research progress in recent years, this article will discuss the cellular regulation and molecular mechanisms of their related genes. Through summarizing the relationship between autophagy and apoptosis,it aims to get a better understanding of the mechanisms of autophagy and apoptosis in tumor progression,and looking at the perspectives for studies on the autophagy and apoptosis in tumor treatment.
