Characteristics and research strategies of patient-derived orthotopic xenograft models
10.3969/j.issn.1671-7856.2018.01.021
- VernacularTitle:人源性肿瘤组织原位异种移植模型的特征及研究策略
- Author:
Xue CHEN
1
;
He ZHANG
;
Changhong SHI
Author Information
1. 成都医学院基础医学院
- Keywords:
patient-derived orthotopic xenograft;
PDOX;
tumor microenvironment;
metastasis
- From:
Chinese Journal of Comparative Medicine
2018;28(1):118-122
- CountryChina
- Language:Chinese
-
Abstract:
The patient-derived orthotopic xenograft (PDOX) model better maintains the genetic characteristics of the primary tumor, and keep stable in histology, transcriptome, polymorphism and copy number variations. It also retains the interaction between the tumor mesenchyma, microvessels and stroma, and the tumor metastatic properties. Therefore, PDOX model can predict disease prognosis more accurately and can be used to screen appropriate individualized treatment strategies, thus, shows perfect prospect in clinical application. However, due to the differences between mouse and human microenvironment, morphological distinctions between orthotopic xenograft tumors and primary tumors still exist, and tumor metastasis can not be ensured by orthotopic xenograft. Thus, in order to construct the individualized PDOX model and to promote its clinical translation, it is necessary to analyze the histomorphology of orthotopic xenografts, to establish database of the transplantation model and share the information of the model. In this review, we will summarize the main features of PDOX models with its advantages and limitations, and looking forward to its application in the future.
