Research progress of CYP450 genes expressed in brain involved in the metabolism of endogenous substances

VernacularTitle:脑内表达的CYP450基因参与内源性物质代谢研究进展
Author: Xinlan YANG ¹ ; Dan LV ; Lianfeng ZHANG
Author Information

1. 中国医学科学院医学实验动物研究所
Keywords: brain tissues; cytochrome P450; endogenous substances; metabolism
From: Chinese Journal of Comparative Medicine 2018;28(1):113-117
CountryChina
Language:Chinese
Abstract: Cytochrome P450 (CYP450) is a superfamily of heme-thiolate proteins, which is involved in the metabolism and activation of various endogenous and exogenous substances, including food, drugs and pollutants. Previous studies of the CYP450 genes mainly focused on their function in drug metabolism. However, in recent years, studies have found that CYP450 are also involved in the development and progression of various diseases, including Parkinson's disease (PD), cancer, cardiomyopathy and heart failure (HF). By far, the process and related mechanisms of CYP450 in the metabolism of endogenous substances in brain tissues has not been clarified yet. In this paper, we summarized the research progress of CYP450 genes involved in the metabolism of endogenous substances, in order to provide a new idea for the exploration of the functions of CYP450 genes expressed in the brain.