Effects of histamine on the motor activity and spatial memory ability in depressive rats
10.3969/j.issn.1671-7856.2018.01.003
- VernacularTitle:组胺对抑郁症大鼠运动欲望与空间记忆能力的影响
- Author:
Yecheng HE
1
;
Juan YAO
;
Shang CHEN
;
Dongyin LI
Author Information
1. 苏州卫生职业技术学院
- Keywords:
histamine;
hippocampus;
rat model of depression;
spatial memory;
motor activity
- From:
Chinese Journal of Comparative Medicine
2018;28(1):16-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of histamine on neurons in the hippocampal C1 area of SD rats and the behavior of depressive SD rats. Methods The effect of histamine on the discharge frequency of neurons in hippocampal C1 area was observed by in vitro extracellular recording of brain slices. The effect of endogenous histamine released to hippocampal neurons was observed through in vivo extracellular recording after the hypothalamus was electrically stimulated. In addition, the changes of motor activity and the ability of spatial memory of the rats with depression after microinjection of histamine into the hippocampal C1 area were observed by open-field test and Morris water maze test. Results The results of in vitro extracellular recording of brain slices showed that the hippocampal neurons were excited by histamine via H1 receptors rather than H receptors in a concentration dependent manner. The results of in vivo extracellular recording showed that endogenous histamine had a bidirectional effect, which means a short-term excitatory effect followed by a long-term inhibitory effect on the hippocampal neurons. After injected with histamine in the hippocampal C1 area,
