Research progress on the application of zebrafish in central nervous system diseases
10.3969/j.issn.1005-4847.2018.03.019
- VernacularTitle:模式动物斑马鱼在中枢神经系统疾病研究中的应用
- Author:
Chunnian HUANG
1
;
Jingjing ZHANG
Author Information
1. 广东医科大学附属医院神经内科
- Keywords:
zebrafish;
central nervous system disease;
model animal
- From:
Acta Laboratorium Animalis Scientia Sinica
2018;26(3):392-397
- CountryChina
- Language:Chinese
-
Abstract:
As a new model animal, zebrafish has been widely used in the research of the development and disease related to various organs, such as nervous, cardiovascular, digestive and hemopoietic system. Central nervous system ( CNS) disease is one of the leading causes of death and disability worldwide. There is still lacking of effective therapeutic strategies to treat most of the CNS diseases, due to the low ability of self-regeneration and recovery of the neurons after injury. In recent years, zebrafish has been proved to be an ideal vertebrate model to study some of the CNS diseases because their genetic physiology and other features are closed and similar to humans. The application of zebrafish in CNS diseases has contributed largely on understanding the mechanisms and on the therapy of CNS diseases. This review summarizes the recent progress of the applications of zebrafish on the study of CNS diseases.
