Immunogenicity and safety of Sabin IPV vaccine in Banna mini pigs
10.3969/j.issn.1005-4847.2018.03.010
- VernacularTitle:Sabin IPV疫苗在版纳小耳猪体内的免疫原性及安全性研究
- Author:
Yina CUN
1
;
Wei CAI
;
Shaohui SONG
;
Jian ZHOU
;
Shengjie OUYANG
;
Wenzhu HU
;
Weidong LI
;
Guoyang LIAO
;
Lei MA
Author Information
1. 中国医学科学院 北京协和医学院 医学生物学研究所
- Keywords:
inactivated poliovirus vaccine derived from Sabin strain ( sIPV );
Banna mini pigs;
safety;
immunogenicity
- From:
Acta Laboratorium Animalis Scientia Sinica
2018;26(3):331-334
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the immunogenicity and safety of inactivated poliovirus vaccine derived from Sabin strain (sIPV) in Banna mini pigs, and to provide experimental evidence for the new animal model. Methods sIPV vaccines which are listed at Institute of Medical Biology at Chinese Academy of Medical Sciences were used in this study. The groups of intramuscular sIPV and the wild strain IPV injections (IPV derived from wild strain, wIPV) were designed, and the saline group was used as a negative control group. The Banna mini pigs in various groups were immunized at 0, 1 and 2 months. Blood samples were collected before immunization and on days 30 after each immunization. Levels of neutralizing antibodies were tested for evaluating immunogenicity. The safety was evaluated by observation of the status and weight of mini pigs. Results After the three dose immunization schedules in the Banna mini pigs, the seroconversion rates of type Ⅰ,Ⅱ and Ⅲ sIPV experimental groups and wIPV group were all up to 100%. The neutralizing antibody levels in all the three types were much higher than the protective titer 1: 8. The weight of mini pigs increased after vaccination. Conclusions The sIPV vaccine has good immunogenicity and safety in Banna mini pigs. Banna mini pigs could be a new animal model for evaluation of sIPV vaccine.
