Effect of noise pollution on serum hormone and Hsp-70 levels in rats
10.3969/j.issn.1005-4847.2018.02.015
- VernacularTitle:噪声污染对大鼠血激素和Hsp-70水平的影响
- Author:
Farong YU
1
;
Yunxuan GUO
;
Xiuzhen LIAN
;
Mingren XIE
;
Denglou LI
;
Wangjun CHEN
;
Bo YANG
;
Shishuang ZHANG
Author Information
1. 甘肃政法学院 甘肃省证据科学技术研究与应用重点实验室
- Keywords:
noise pollution;
hormone;
heat shock protein-70;
Wistar rat
- From:
Acta Laboratorium Animalis Scientia Sinica
2018;26(2):230-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of noise pollution on serum hormone and heat shock protein-70(Hsp-70)levels in rats. Methods Forty male Wistar rats were randomly divided into control group(normal), experimental group(further divided into 35,65 and 85 dB three groups), each group 10 animals, stimulated for 30 min once a day, continually stimulated for consecutive 20 days. On the 21st day of experiment,the serum noradrenaline(NA),testosterone (T),dopamine(DA)and Hsp-70 levels were determined by enzyme-linked immunosorbent assay(ELISA). Results Compared with the control group, the body weight of experimental group(35, 65 and 85 dB groups)was reduced by 23.45%,30.13%, and 35.64%, respectively The serum T and DA levels were decreased by 9.12%, 20.06%, 37.99% and 15.49%, 8.31%, 24.88%, respectively; while the serum NA and Hsp-70 levels were increased by 35.08%, 171.52%,197.86%, and 39.34%, 195.09%, and 285.25%, respectively. All the result showed a significant difference(P<0.01). Conclusions Noise pollution can significantly affect the serum levels of hormone and heat shock protein-70 expression in rats.
