Changes of gray matter volume in patients with bipolar disorder and suicidal ideation: a voxel based morphometric analysis
10.3969/j.issn.1002-0152.2018.11.006
- VernacularTitle:有自杀意念双相障碍患者脑灰质体积形态测量分析研究
- Author:
Chang ZHANG
1
;
Ran ZHANG
;
Shengnan WEI
;
Fei WANG
Author Information
1. 沈阳市精神卫生中心 沈阳110168
- Keywords:
Bipolar disorder;
Suicidal ideation;
Gray matter volume;
Voxel-based morphometry
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(11):668-672
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study aims to analyze the changes in gray matter among Bipolar Disorder (BD) with suicidal ideation, those without suicidal ideation and health control (HC) and to explore the altered brain imaging changes of BD patients with suicidal ideation. Method The study recruited 28 BD with suicidal ideation, 40 BD without suicidal ideation and 46 HCs who undergone the high-resolution structural magnetic resonance imaging. Thus, the data of all participants were analyzed by voxel-based morphometry (VBM). Results Significantly decreased gray matter volume was detected in the right superior temporal gyrus, right middle temporal gyrus, left caudate nucleus, left lenticular putamen, left middle occipital gyrus and left occipital gyrus in patients with BD compared to HCs. However, there was no significant difference in gray matter volume between BD with suicidal ideation and those without suicidal ideation. There were significant differences in gray matter volume in the right postcentral, the right superior parietal gyrus and the right precuneus among BD with and without suicidal ideation and HCs. The gray matter volumes of BD with suicidal ideation were significantly lower than that of the other two groups. Conclusion Gray matter volume abnormalities in parietal lobe play an important role in the brain structural alternation of BD with suicidal ideation.
