The clinical and radiological features of MOG antibody positive demyelinating diseases of central nervous system
10.3969/j.issn.1002-0152.2018.11.002
- VernacularTitle:MOG抗体阳性视神经脊髓炎谱系疾病临床和影像学特点
- Author:
Haiyan YAO
1
,
2
;
Qingmei HUANG
;
Wei QIU
;
Huiming XU
;
Tianni LIU
;
Huacai YANG
;
Baikeng CHEN
;
Si LIU
;
Cong GAO
;
Youming LONG
Author Information
1. 广州医科大学附属第二医院神经内科 广州510260
2. 广州医科大学附属第二医院神经科学研究所
- Keywords:
Neuromyelitis optica spectrum disorder;
Myelin oligodendrocyte glycoprotein;
Clinical features;
Magnetic resonance imaging
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(11):646-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective Our study aimed to delineate the clinical and radiological features of patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)positive neuromyelitis optica spectrum disorder (NMOSD). Methods Fifty-seven patients with NMOSD and 29 patients with multiple sclerosis (MS) were collected. Data on clinical and radiological features of MOG-Ab positive patients with were analyzed retrospectively. Results MOG-Abs were present in 9/57 (15.8%) NMOSD patients and 2/29 (6.9%) MS patients. Both MOG and aquaporin-4 (AQP4) antibodies were positive in one case of NMOSD. There was no significant difference between the two groups (P＞0.05). There were more females than males having MOG-Ab positive NMOSD (females: males=7:1) and the average onset age was 41.4 ± 11.5 years. There was no significant difference in gender and age between MOG-Ab negative and AQP4-Ab positive groups(P＞0.05). The durations of disease were significantly shorter in either MOG-Ab positive NMOSD patients or MOG-Ab negative NMOSD patients than in AQP4-Ab positive group (P<0.05). Recurrence was the main disease pattern of all three groups and the frequency of recurrence was not significant different among three groups (P＞0.05). The incidence of optic neuritis was 62.5% in NMOSD patients with MOG-Ab positive and 43.5% in AQP4-Ab positive NMOSD patients (P＞0.05). There was no significant difference in the morphology and location of brain lesions among the three groups (P＞0.05). MOG-Ab positive NMOSD patients had long segment spinal cord lesions. The median length of the spinal cord lesions in the MOG-Ab positive group was similar to the other two groups (P＞0.05). Conclusions MOG-Ab positive NMOSD patients have higher proportion of females with shorter recurrence course, more likely complicated with optic neuritis. And the radiological features of brain and spinal cord were not specific to patients with AQP4-Ab positive.
