Analysis of clinical features of brainstem encephalitis manifested as Parkinson syndrome
10.3969/j.issn.1002-0152.2018.05.004
- VernacularTitle:表现为帕金森综合征的青年脑干脑炎临床特点分析
- Author:
Jiaomei JIANG
1
;
Ming ZHANG
;
Xueliang QI
Author Information
1. 南昌大学附属第二医院神经内科 南昌 330006
- Keywords:
Brainstem encephalitis;
Symmetric midbrain lesions Postencephalitic;
Parkinsonism
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(5):272-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical manifestations and imaging features of human brainstem encephalitis with Parkinson syndrome as the main manifestations. Methods Combined with related literature, the clinical, laboratory and imaging features of three patients with brainstem encephalitis, which were mainly manifested as Parkinson syndrome, were analyzed. Results The 3-hour video EEG showed normal in 2 cases and abnormal in one case with more delta wave in each leads. Cerebrospinal fluid examination revealed normal cell numbers in one case, increased cell numbers in 2 case and elevated cerebrospinal fluid proteins in all 3 cases. serum and CSF IgG anti-NMO antibodies as well as autoimmune encephalitis antibodies were negative in 3 cases. Brain MRI showed symmetrical abnormal signal in bilateral midbrain and pia mater enhancement increased in 3 cases. After hormone, and madopar treatment, Parkinson syndrome symptoms were significantly improved in two patients. Conclusion Brainstem encephalitis-induced symmetrical midbrain lesion can manifest as Parkinson syndrome. The laboratory tests reveal an involvement of immune system and hormone therapy may be effective.
