A retrospective study of antiepileptic drugs, etiology and seizure patterns in hospitalized patients with epilepsy
10.3969/j.issn.1002-0152.2018.05.003
- VernacularTitle:癫痫住院患者抗癫痫药物和病因及发作形式的回顾性研究
- Author:
Junqiang LI
1
;
Pengpeng LIU
;
Tiaowen LING
;
Yuzhe GONG
;
Lu TIAN
;
Zhenyu FAN
;
Tiancheng WANG
Author Information
1. 兰州大学第二医院癫痫科 兰州 730000
- Keywords:
Epilepsy;
Inpatients;
Anticonvulsants
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(5):266-271
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate and analyze the etiology, seizure type and anti-epileptic drugs (AEDs) utilization of in-patients with epilepsy Methods The study included 5563 cases in-patients with epilepsy. The etiology and seizure type and the date of type, quantity of AEDs in-patient department were collected and their usage frequency were analyzed statistically. Results The most common etiology of epilepsy was traumatic brain injury(13.64%), followed by hippocampal sclerosis (11.52%), stroke (5.24%), nervous system infection (4.98%), perinatal injury ( 5 . 28 % ) and undefined etiology ( 40 . 80 % ) . The most common seizure type was partial seizures (45.43% ). The AEDs of carbamazepine and valproate were the most common used drugs in the clinical and their average usage frequency were 36.88% and 30.80%, respectively. The newer AEDs of Lamotrigine and Levetiracetam were used more frequently. The use of Lamotrigine increased from 16.16% to 28.44% and the Levetiracetam from 0.61% to 20.87% whereas the use of Oxcarbazepine and Topiramate remained a stable level of 15.07% and 9.42%. Conclusion The etiology of epilepsy is complicated and the seizure type of epilepsy was diverse. Among a great variety of anti-epileptic drugs, the newanti-epileptic drugs are being increasingly used.
