Effects of aripiprazole on clinical symptoms and serum neurotrophic factor levels in patients with schizophrenia
10.3969/j.issn.1002-0152.2018.04.006
- VernacularTitle:阿立哌唑对精神分裂症患者临床症状及血清神经营养因子水平的影响
- Author:
Qigen WAN
1
;
Jinqiong ZHAN
;
Yuanjian YANG
;
Yonghui FU
;
Jianwen XIONG
;
Zhipeng LIU
;
Kun YAN
;
Haibo CHEN
;
Yating TU
;
Bo WEI
Author Information
1. 江西省精神病院
- Keywords:
Aripiprazole;
Schizophrenia;
Nerve growth factor (NGF);
Brain derived neurotrophic foctor (BDNF);
Neurotrophin 3 (NT-3)
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(4):217-221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of aripiprazole on clinical symptoms and neurotrophic factor levels in patients with schizophrenia. Methods Forty patients with schizophrenia and 40 normal controls were included in the study. The clinical symptoms of patients receiving aripiprazole only for 12 weeks were evaluated by using the Positive and Negative Syndrome Scale (PANSS). Stroop Color-Word Test (SCWT), Continuous Performance Test, Digit-Symbol Coding Test and Trail Making Test-A were used to evaluate the cognitive function both in patients and controls. Serum levels of Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF) and Neurotrophin 3 (NT-3) were measured using enzyme linked immunosorbent assay. Results The clinical scores, cognitive function and levels of neurotrophic factors were different before and after treatment (P<0.01). And those were significantly lower in patients than in control group (P<0.05). Before treatment, BDNF was negatively correlated with PANSS negative symptom score (r=-0.362, P=0.022);NGF was related to the total score of PANSS (r=0.332, P=0.037) and positive symptoms (r=0.401, P=0.010); NT-3 was associated with negative symptom scores (r=-0.376, P=0.017) and SCWT-color words (r=0.332, P=0.037) in patient group. After treatment, the increase in BDNF was correlated with the reduction in PANSS total score (r=0.371, P=0.018), negative symptom score (r=0.345, P=0.029) and general pathology score (r=0.342, P=0.031). There was a correlation of the increase of NGF with the decrease of PANSS total scores (r=0.437, P=0.005) and with positive symptom scores (r=0.357, P=0.024). Conclusion Treatment with Aripiprazole can improve the clinical symptoms and cognitive functiona impairments in patients with schizophrenia, which may be related to the increase in serum levels of BDNF, NGF and NT-3.
