Investigation of orbitofrontal sulcogyral pattern in children and adolescents with schizophrenia
10.3969/j.issn.1002-0152.2018.03.007
- VernacularTitle:儿童青少年精神分裂症患者眶额脑回沟区结构模式
- Author:
Haisan ZHANG
1
;
Yan LI
;
Yun LI
;
Kun LI
;
Bi WANG
;
Suqin GUO
;
Luxian LYU
;
Hongxing ZHANG
Author Information
1. 新乡医学院第二附属医院 新乡453002
- Keywords:
Schizophrenia;
Children and adolescents;
Orbitofrontal sulcogyral pattern;
Magnetic resonance imaging
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(3):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the structural patterns of orbitofrontal sulcogyral pattern (OSP)and the susceptibility to schizophrenia in children and adolescents patients with schizophrenia. Methods Seventy-two childhood and adolescence schizophrenia aged 6~18 years were enrolled as the case group and 78 sex-, age-, education-matched healthy children served as the control group. MR images were acquired with a 3.0 T Magnetom Symphony MRI system. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the symptom severity of patients.The pattern type of OFC was classified based on continuity among medial (MOS),lateral (LOS)and transverse (TOS) orbital sulci according to the method of Chiavaras and Petrides'. The orbitofrontal cortex (OFC) sulcogyral pattern was classified into three types(TypeⅠ,TypeⅡ,TypeⅢ)in each hemisphere. Results There were significant differences in the distribution of OFC patterns between the control and the case group (Left hemisphere: Χ2=6.668,P=0.036; Right hemisphere: Χ2=7.501,P=0.024). The linear regression analysis showed that Type Ⅲ in either hemisphere was associated with more severe symptoms in schizophrenia patients (B=7.214, P=0.008). Conclusions Type Ⅲ sulcogyral pattern may be a morphological risk marker for schizophrenia. Compared to the other two types, the Type Ⅲ expression is associated with more severe clinical symptoms.
