Relationships of polymorphism of APOE gene and cognitive impairment in patients with CNS demyelinat-ing diseases
10.3969/j.issn.1002-0152.2018.02.006
- VernacularTitle:中枢神经系统脱髓鞘疾病患者APOE基因多态性与认知功能的关系
- Author:
Meng CAO
1
;
Zhu XU
;
Dian HE
;
Bing SHAO
;
Qinhua WU
;
Mao MOU
;
Yanxiao MENG
;
Lan CHU
Author Information
1. 贵州医科大学附属医院神经内科 贵阳550004
- Keywords:
Central nervous system;
Multiple sclerosis;
Neuromyelitis optica spectrum disorder;
Cognitive impairment;
ApoE Gene
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(2):90-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the level of polymorphism of APOE gene and cognitive impairment in patients with CNS demyelinating diseases. Methods 56 patients with central nervous system demyelinating disease were applied APOE genotyping,MoCA and expanded disability status (EDSS) scale score. Patients with MOCA scores <26 were divided into cognitive impairment group, and those with MOCA scores ≥26 were divided into normal cognitive preserved group. Results The probability of cognitive dysfunction in patients with central nervous system demyelinating diseases was 53.57%. There was no significant difference in age, gender, and disease duration between the CI group and the CP group(P>0.05), the difference in age and education among groups is statistically significant (P<0.05). There was no statistical significance in the difference in age, sex, education years and EDSS score between APOEε4 gene positive group and APOEε4 gene negative group (P<0.05). The difference of visual space and attention between different cognitive domains is statistically significant(P<0.05). Years of schooling is a risk factor for cognitive dysfunction in patients with central nervous system demyelinating disease(P<0.01). Conclusion The central nervous system demyelinating disease is impaired cognitive function. Patients with APOEε4 gene positive are more severely impaired in visual space and attention than patients with negative APOEε4 gene.Years of education are the risk factors of cognitive dysfunction in patients with central nervous system demyelinating disease. The course of disease and disabled function may not be significant related to cognitive impairment.
