Changes of serum neuropeptide Y and therapeutic intervention in patients with schizophrenia after drug therapy
10.3969/j.issn.1002-0152.2018.02.004
- VernacularTitle:精神分裂症药物治疗后血清神经肽Y变化与治疗干预的关系
- Author:
Jing ZHAO
1
;
Qinyu LYU
;
Yin LU
;
Guoqin HU
;
Chenxi BAO
;
Minghuan ZHU
;
Si JIA
;
Xiaoyan CHENG
;
Ruijie GENG
;
Yingyi WANG
;
Weibing MAO
;
Jian XU
;
Shunying YU
;
Zhenghui YI
Author Information
1. 上海交通大学医学院附属精神卫生中心 上海200030
- Keywords:
Neuropeptide Y;
Schizophrenia;
Cognitive function;
Psychiatric symptoms
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(2):80-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the serum neuropeptide Y (NPY) levels and the pathogenesis,therapeutic intervention of schizophrenia. Methods One hundard twenty-five patients with schizophrenia (case group) with no medication for at least 4-week and 136 healthy controls (control group) were evaluated by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Positive and Negative Syndrome Scala (PANSS). Simultaneously blood tests were performed to detect serum NPY levels. In the case group, PANSS was evaluated and blood collected again after 4 weeks of treatment with olanzapine. Result At the baseline,the serum NPY concentration was significantly lower in the case group than in control group (t=-5.79, P<0.01). The scores of RBANS and its factors were significantly lower in the case group than in control group (all P<0.01). The concentration was positively correlated with the score of the attention factor for RBANS scale (r=0.20, P=0.04). After treatment with olanzapine for 4 weeks,the serum NPY level in the case group was significantly increased (t=-2.23,P=0.03).The scores of PANSS total scale and subscale were significantly decreased(all P<0.01).There was no significant correlation between alterations of the serum level of NPY and PANSS total or subscale scores from baseline to 4-week (all P>0.05). Conclusion The present study has revealed a significant decrease in serum NPY levels in patients with schizophrenia which can be attenuated by treatment of Olanzapine.The action of Olanzapine may be related to the mechanism of action of Olanzapine.However,there is no correlation between alterations of the serum level of NPY and the improvement in the patientˊs clinical symptoms.
