Influence of duration of untreated psychosis on cognition and social function in first-episode drug-na?ve schizophrenia.
10.3969/j.issn.1002-0152.2018.01.008
- VernacularTitle:首发精神分裂症精神病未治期对认知功能和社会功能的影响
- Author:
Yanan ZHOU
1
;
Jinguo ZHAI
;
Min CHEN
Author Information
1. 济宁医学院第二附属医院精神科
- Keywords:
First-episode schizophrenia;
Duration of untreated psychosis;
Cognition;
Social function
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(1):38-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of duration of untreated psychosis (DUP)on cognition and social function in first-episode drug-na?ve schizophrenia. Methods Ninety-three first-episode drug-na?ve schizophrenic were enrolled as the schizophrenia group and 93 normal people served as the control group. The Positive and Negative Symptoms Scale (PANSS) were used to assess the degree of mental symptoms. The Matrics Consensus Cognitive Battery (MCCB) was used to evaluate the cognitive function. Personal and Social Performance Scale (PSP) and the Global Assessment Function Scale (GAF) were used to evaluate the social function. Result There were significant differences in scores of Trail Marking Test, Symbol Coding test, Category Fluency test, Stroop color word test, Continuous Performance Test, Spatial Span test, Brief-Visuospatial Memory Test-Revised (HVLT-R), Brief-Visuospatial Memory Test-Revised (BVMT-R) and Maze test between the schizophrenia group and the control group (all P<0.05). There were significant differences in scores of GAF and PSP between the schizophrenia group and the control group (all P<0.05). DUP was negatively related to the score of HVLT-R2 (r=-0.265, P=0.010) or BVMT-R3 (r=-0.328, P=0.001). DUP was negatively related to the scores of GAF score(r=-0.292,P=0.005)or PSP score(r=-0.397,P<0.001). Conclusion There are social function impairment and a wide range of cognitive function impairment in the first-episode drug-na?ve schizophrenic. The length of the DUP is associated with the severity of the social functional and cognitive functional impairment.
