A clinical analysis of patients with AQP4-IgG and MOG-IgG seropositive.
10.3969/j.issn.1002-0152.2018.01.006
- VernacularTitle:水通道蛋白4和髓鞘少突胶质细胞糖蛋白抗体阳性患者临床分析
- Author:
Xinmei KANG
1
;
Xiaobo SUN
;
Jing LI
;
Chen CHEN
;
Tingting LU
;
Yaqing SHU
;
Hui YANG
;
Zhanhang WANG
;
Xiaojing LI
;
Xueqiang HU
;
Zhengqi LU
;
Wei QIU
;
Lisheng PENG
Author Information
1. 中山大学附属第三医院神经内科
- Keywords:
Aquporin 4;
Myelin oligodendrocytes glycoprotein antibody;
Neuromyelitis optica spectrum disorder
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(1):26-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the seropositive ratio of the antibody to aquporin 4 (AQP4-IgG) and myelin oligodendrocytes glycoprotein antibody(MOG-IgG)in patients with autoimmune-associated central nervous system (CNS) diseases. Meanwhile, epidemiology and clinical manifestation and diagnosis,laboratory examination and magnetic resonance imaging(MRI)of AQP4-IgG seropositive and MOG-IgG seropositive patients are described. Methods 2068 patients serum samples were collected and enrolled in the multi-center research. The methodology of cell-mediated immunofluorescence staining was used to detect serum AQP4-IgG and MOG-IgG. Clinic medical records were collected and characteristics of epidemiology and manifestation were compared. Results 681 patients were AQP4-IgG seropositive and 110 patients were MOG-IgG seropositive. The female/male ratio and age of onset of patients with AQP4-IgG seropositive(616 female and 65 male,female:male=9.50:1.00;Age of onset=41.7±14.9)were significantly higher than that of patients with MOG-IgG (57 female and 53 male, female:male=1.08:1.00, P<0.0001; Age of onset=27.0 ±17.7, P<0.0001). The optic neuritis was significantly higher in patients with AQP4-IgG seropositive and patients with MOG-IgG seropositive (38.4% vs.53.5%, P<0.05).Among patients with AQP4-IgG seropositive, 42.14% conformed the diagnostic criteria of neuromyelitis optica (NMO),which was higher than that of patients with MOG-IgG seropositive (13.64%, P<0.0001). Laboratory examination showed that there was no significant difference in cerebrospinal fluid protein levels between patients with AQP4-IgG seropositive and those with MOG-IgG seropositive.MRI imaging suggested that AQP4-IgG positive patients were more common in cervical thoracic spinal cord lesions, while MOG-IgG positive patients were more involved in thoracolumbar spinal cord. The study also found that these two groups of patients could be comorbid with other autoimmune antibodies. Conclusions This multi-center research has revealed that patients with AQP4-IgG seropositive and those with MOG-IgG seropositive display differences in epidemiology,clinic manifestations and diagnosis,laboratory examination and MRI imaging. AQP4-IgG and MOG IgG auto-antibody detection are necessary for clinic diagnosis and differential diagnosis.
