The study of association between PTEN gene polymorphisms and schizophrenia of HAN ethnic with type 2 diabetes mellitus in Shanghai
10.3969/j.issn.1002-0152.2017.12.007
- VernacularTitle:上海地区汉族PTEN基因多态性与精神分裂症伴发2型糖尿病的关联分析
- Author:
Ying LU
1
;
Jing ZHAO
;
Qinyu LYU
;
Chenxi BAO
;
Ruijie GENG
;
Xiaoyan CHENG
;
Yingyi WANG
;
Qi GU
;
Yuting LI
;
Chen ZHANG
;
Shunying YU
;
Zhenghui YI
Author Information
1. 上海交通大学医学院附属精神卫生中心,上海200030
- Keywords:
Schizophrenia;
PTEN gene;
Type 2 diabetes mellitus
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(12):737-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the correlation between the gene of phosphate and tension homology deleted on chromosometen (PTEN gene) polymorphism and schizophrenia (SCZ) associated with the type 2 diabetes mellitus (T2DM ) in Shanghai Han population. Methods The study recruited 591 long-stay schizophrenic inpatients including 304 with and 287 without type 2 diabetes mellitus, 206 patients with the type 2 diabetes mellitus and 205 normal subjects from Shanghai Han population. SNPs of PTEN gene (rs1234225, rs12569998, rs1234223) were genotyped by using Taqman genotyping. The frequency distributions of allele, genotype and haplotype between groups were analyzed. Results There were significant differences in the frequency of rs1234223 genotype (P=0.01) and allele distribution (P=0.02) between the SCZ with type 2 diabetes mellitus group and the SCZ without type 2 diabetes mellitus group. The difference of genotype frequencies remained statistically significant (P=0.03) but the allele distribution was not (P=0.06) after Bonferroni correction. Haplotype analysis showed that TTC haplotype was less common in the SCZ with type 2 diabetes mellitus group than in the SCZ without type 2 diabetes mellitus group (P=0.02). Conclusions PTEN gene may be a susceptibility gene for schizophrenia with type 2 diabetes mellitus in Chinese Han population. The TTC haplotype may be a protective factor for schizophrenia with type 2 diabetes mellitus.
