Resting state functional connectivity analysis of the frontal lobe-amygdala in different age paragraph female patients with bipolar disorder
10.3969/j.issn.1002-0152.2017.12.002
- VernacularTitle:不同年龄阶段女性双相障碍前额叶—杏仁核功能连接比较研究
- Author:
Yinzhu MA
1
;
Shengnan WEI
;
Zhiyang YIN
;
Xuesheng FAN
;
Dahai WANG
;
Yanqing TANG
;
Fei WANG
Author Information
1. 中国医科大学附属第一医院精神医学科
- Keywords:
Female;
Bipolar disorder;
Prefrontal lobe;
Amygdala;
Founctional connectivity
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(12):710-714
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find frontal lobe-amygdala functional connections in different age paragraph female patients with bipolar disorder. Methods The FMRI date were acquired from 30 patients with bipolar disorder aged 13 to 25 years old and 30 age-and education level-and gender-matched health controls.FMRI was also conducted on 30 patients with bipolar disorder aged 26 to 45 years old and 30 age-and education level-and gender-matched health controls.The date was calculated by using MATLAB based DPARSF software. Results Compared with corresponding health controls, the lobe-amygdala functional connections significantly decreased in patients aged 13 to 25 years but remained unchanged in patients aged 26 to 45 years old. Conclusions The decrease in the frontal lobe-amygdala functional connections decreased in female patients aged 13 to 25 years old may be related to the underdevelopment in vulnerable immature brain.In contrast, the frontal lobe-amygdala functional connections in female patients aged 26 to 45 years old remain intact.
