A risk factors analysis on biochemical remission of pituitary tumor patients with acromegaly treated by the endoscopic endonasal surgery
10.3969/j.issn.1002-0152.2017.11.006
- VernacularTitle:神经内镜经鼻蝶入路治疗伴肢端肥大症垂体肿瘤生化指标缓解因素分析
- Author:
Changzhen JIANG
1
;
Dezhi KANG
;
Yuanxiang LIN
;
Fei HE
;
Chenyang WANG
;
Xiaorong YAN
Author Information
1. 福建医科大学附属第一医院神经外科 福州350005
- Keywords:
Endoscopic endonasal surgery;
Acromegaly;
Biochemical remission;
Risk factor
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(11):667-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors of the biochemical remission of pituitary tumor patients with acromegaly treated by the endoscopic endonasal surgery. Methods A retrospective analysis of clinical data was conducted on 61 cases acromegaly patients underwent endoscopic endonasal surgery between August 2013- November 2016.Endocrinology tests were performed in all patients,including the fasting/random GH(growth hormone,GH)level, Nadir GH during OGTT(oral glucose tolerance test, OGTT), and IGF-1(insulin-like growth factor-1,IGF-1). The clinical data included gender, age, preoperative GH value, preoperative IGF-1 value, tumor invasion of the inferface space of internal carotid artery(ICA),tumor surrounding angle of internal carotid artery(≥/<135°),Knosp grade, Hardy grade, and tumor volume. Univariate analysis and multivariate Logistic retrospective analysis were used to analyze the association between above-mentioned factors and the occurrence of biochemical remission. Results There were 52.5% (32/61)patients achieving biochemical remission.Univariate analysis showed significant differences between patients with and without biochemical remission in preoperative GH value, tumor surrounding angle of internal carotid artery(
