The analysis on the risk factors of infection after cerebral infarction
10.3969/j.issn.1002-0152.2017.11.003
- VernacularTitle:脑梗死后卒中相关性感染的危险因素
- Author:
Binglin FAN
1
;
Lvli LI
;
Junjie WEI
;
Weizhang ZHONG
;
Zhi CHEN
;
Yanhua LI
Author Information
1. 广西壮族自治区人民医院神经内科 南宁530021
- Keywords:
immunosuppression;
poststroke infection;
cerebral infarction
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(11):651-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of poststroke infection after cerebral infarction. Methods We consecutively included 283 patients with acute ischemic infarcts confirmed by diffusion-weighted imaging (DWI) within 72 hours from Guangxi stroke center. Based on infection status, patients were divided into Not infection group(n=198) and infection group (n=85). The serum cortisol and plasma IL-4 were assessed using chemiluminescent system and double antibody sandwich enzyme linked immunosorbent assay at admission and seventh day later,respectively. Results Compare to no infection group, smoking, mechanical ventilation, diabetes mellitus, dysphagia, COPD,level of consciousness, cortisol and IL-4 at admission, NIHSS, middle area and large area infarction, large atherosclerosis and cardiogenic infarction, left side,both side and subtentorial infarction are more liable to infection(P<0.05);After a Single-factor and Multivariate analysis,we found that cortisol(OR 3.26)and IL-4(OR 2.83)at admission,large area infarction(OR 2.67),left side(OR 3.78)and subtentorial infarction(OR 3.12)were significant correlated with infection, suggesting that they might be the independent risk factors for infection after cerebral infarction. Conclusion Immunological factors and different regional cerebral infarction may increase susceptibility to infection after stroke.
