Relationship between plasma tau protein , p-tau protein and cognitive function in elderly patients with global brain atrophy
10.3969/j.issn.1002-0152.2017.10.007
- VernacularTitle:广泛性脑萎缩者血浆tau蛋白、磷酸化tau蛋白水平与认知功能的关系
- Author:
Xiaozhu SHEN
1
;
Yan DONG
;
Lingling WANG
;
Chen GONG
;
Pengxiang GAO
;
Qinwen BAO
;
Xin WANG
;
Changrong TIAN
Author Information
1. 江苏省连云港市第二人民医院老年医学科 连云港市222006
- Keywords:
Atrophy;
Cognition disorder;
Tau protein;
Dementia
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(10):608-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between plasma tau protein, phosphorylated tau protein (p-tau) protein and cognitive function in subjects with generalized brain atrophy. Methods A total of 100 subjects with moderate and severe brain atrophy were divided into two groups according to cognitive function: normal group (n=50 cases) and dementia group (n=50 cases). And their gender, age, educational level, etc. are recorded. The tau protein and p-tau protein content in plasma were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). The differences between plasm tau and p-tau protein expression and their relationship with cognitive function were analyzed. Results Plasma tau protein and p-tau protein levels were significantly higher (P<0.05) in the dementia group [(210.92±43.79)pg/mL、(81.15±16.85)pg/mL] than in the normal group[(210.92±43.79)pg/mL、(81.15±16.85)pg/mL]. Plasma tau protein and p-tau protein levels were negatively correlated with the MMSE score (P<0.05) and had no significant correlation with the degree of brain atrophy (P>0.05). Conclusion Cognitive impairment may be associated with elevated tau protein levels in patients with extensive brain atrophy.
