Research progress on autophagy-related protein 5 and BECLIN-1 regulate autophagy and apoptosis
10.3969/j.issn.1002-2694.2018.00.026
- VernacularTitle:自噬相关蛋白ATG5/BECLIN-1调控细胞自噬和凋亡的分子机理研究进展
- Author:
Kun XIE
1
;
Mi-Jie LI
;
Chen-Yan JIANG
;
Hai-Ju LU
;
Qiong KONG
;
Bo GAO
;
Wan-Ying YANG
Author Information
1. 红河学院 生命科学与技术学院
- Keywords:
autophsgy-related protein 5;
BECLIN-1;
au-tophagy;
apoptosis;
molecular mechanism;
regulate
- From:
Chinese Journal of Zoonoses
2018;34(3):272-275,285
- CountryChina
- Language:Chinese
-
Abstract:
ATG5 and BECLIN-1 belong to two kind of crucial autophagy-related proteins included the formation of autoph-agosomes,in addition to the promotion of autophagy,enhances susceptibility towards apoptotic stimuli,therefore,ATG5 and BECLIN-1 are considered to be a molecular link between autophagy and apoptosis.Preliminary data revealed that ATG5 media-ted the formation of autophagosomes by ATG5-ATG12-ATG16L ubiquitination system,while BECLIN-1 induces autophagy by phosphatidylino3-kinase (PtdIns3KC3)complex.But now it is believed that truncated ATG5(tATG5-N)and truncated BEC-LIN-1(BECLIN-1-C),an amino-terminal cleavage product of ATG5 and carboxyl-terminal cleavage product of BECLIN-1, could induce apoptosis.The research summarize the progress on ATG5 and BECLIN-1 regulated autophagy and apoptosis,so as to further reveal the molecular mechanism of they regulate autophagy and apoptosis.
