Advance in toxic and pathogenic mechanisms of bacterial hemolysins
10.3969/j.issn.1002-2694.2018.00.022
- VernacularTitle:细菌溶血素毒性和致病机制研究进展
- Author:
Bi-Shu MA
1
;
Li-Na MA
;
Xu-Ai LIN
;
Jie YAN
Author Information
1. 昆明医科大学海源学院微生物学和免疫学教研室
- Keywords:
bacterial hemolysins;
membrane injury;
cell disruption;
cell apoptosis;
inflammatory reaction
- From:
Chinese Journal of Zoonoses
2018;34(2):175-181
- CountryChina
- Language:Chinese
-
Abstract:
Many bacterial pathogens can produce hemolysins to lyse erythrocytes,but recent studies revealed that bacterial hemolysins could cause injury and death of many nucleated cells and platelets.According to the difference of molecular structure,cell-binding manner and membrane pore-forming mechanism,most of bacterial hemolysins are classified into the toxins belonging to either repeats in toxin family (RTX) or cholesterol-dependent cytolysin family (CDC).Bacterial hemolysins play important pathogenic roles during infection of bacteria through membrane damage,cell lysis or disruption,ion disequilibriumassociated pathological changes,cell apoptosis or cell necroptosis as well as through TLR2/4-mediated NF-κB,p38MAPK,JNK signaling pathways and NLRs-mediated NLRP3 inflammasomes to cause powerful inflammatory reaction and inflammatory tissue injury.
