Association of mycoplasma infection with genital system tumor: A system evaluation
10.3969/j.issn.1002-2694.2017.12.006
- VernacularTitle:支原体感染与生殖系统肿瘤关联性研究的系统评价
- Author:
Xiang HONG
1
;
Yue-Qi YIN
;
Da-Shuai LIAN
;
Man YANG
;
Bei WANG
Author Information
1. 东南大学公共卫生学院流行病与卫生统计学系
- Keywords:
mycoplasma;
genital system;
cancer;
meta analysis
- From:
Chinese Journal of Zoonoses
2017;33(12):1082-1088
- CountryChina
- Language:Chinese
-
Abstract:
We explore the association of the mycoplasma infection with genital system tumor.Some index word including prostate cancer,cervical cancer,ovarian cancer and mycoplasma were used in some electronic databases (including PubMed,Web of Science,Chinese biomedical database,wanfang database,CNKI) to search literatures.The R software was used for the meta-analysis.The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the literature.Publication bias was evaluated by funnel figure,and the fail-safe number (Nfs) was calculated to estimate the reliability of the meta-analysis.Result showed that 20 articles were included,the numbers of cases and controls were 2 345 and 2 728 respectively.The pooled OR of Ureaplasma urealyticum(Uu),Mycoplasma hominis(Mh),other mycoplasma,mixture of mycoplasma and the whole mycoplasma was 2.19(95％CI:1.27-3.79),1.74(95％CI:1.28-2.35),1.97(95％CI:1.03-3.77),3.54 (95％CI:1.33-9.41),1.29(95％CI:1.53-2.60),respectively.The fail-safe number of Uu,Mh,other mycoplasma and mixture of mycoplasma was 254,42,31,157 respectively.There are some possibility about the association between the mycoplasma infection and the genital system cancer;maybe the infection would increase the tumorigenesis risk.It is necessary to research further about these associations in different mycoplasmas respectively.
