High level IFN-γ may be one of the characteristics of chronic brucellosis
10.3969/j.issn.1002-2694.2017.08.010
- VernacularTitle:高水平IFN-γ可能是布鲁杆菌病慢性化的特征之一
- Author:
Li-Hong HAN
1
;
Ri-Hong LIU
;
Zhi-Guo LIU
;
Bu-Yun CUI
Author Information
1. 包头医学院医学技术学院临床生化教研室
- Keywords:
brucellosis;
gamma interferon;
transforming growth factor β1
- From:
Chinese Journal of Zoonoses
2017;33(8):716-719
- CountryChina
- Language:Chinese
-
Abstract:
We sought to compare the level of peripheral blood gamma interferon(IFN-γ),interleukin 4 (IL-4),TGF-β1,IL-10 and IFN-γ/IL-4 between acute brucellosis and chronic brucellosis to look for biochemical markers for chronic brucellosis.A total of 42 acute brucellosis and 42 chronic brucellosis cases were selected randomly from the Endemic Disease Prevention and Control Center of Ulanqab City as the research subjects with 20 local healthy persons as healthy control.Comparisons of IFN-γ,IL-4,TGF-β1,IL-10 and IFN-7/IL-4 in the three groups were tested by One-Way ANOVA analysis.Parameters of IL-4,IFN-γ,TGF-β1,IL-10 and IFN-γ/IL-4 in peripheral blood were analyzed with T-test between acute brucellosis with chronic brucellosis.Results showed that the mean of IFN-,IL-4,TGF-β1 and IFN-γ/IL-4 was significant difference in the three groups(F =6.86,11.90,12.25,4.60,P＜0.01),but not of IL-10(F=2.72,P＞0.05).The mean of IFN-γ,IL-4 andIFN-7/IL-4 was significant difference between acute brucellosis with chronic group(t=-1.99,82,-3.3,P＜0.05),but not of TGF-β1 and IL-10(t=-1.90,-1.81,P＞0.05).Combined with TGF-β1 and IL-10 levels,high level IFN-γ may be regarded as one of the biochemical markers for chronic brucellosis.
