Study of the Disease Free Intervals of the Patients with No Evidence of Disease by FDG-PET after Treatment and the Feasibility of FDG-PET as Follow up method.
- Author:
Chun Sook PARK
1
;
Jeong Jin KANG
;
Hae Rim SHIN
;
Myung In KIM
;
Moon Hong KIM
;
Ki Jeong CHUN
;
Sung Eun KIM
;
Beob Jong KIM
;
Seok Chul CHOI
;
Sang Young RYU
;
Eui Don LEE
;
Kyung Hee LEE
Author Information
1. Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cervical cancer;
DFI;
FDG-PET;
Recurrence
- MeSH:
Follow-Up Studies*;
Humans;
Liver;
Lung;
Lymph Nodes;
Neoplasm Metastasis;
Recurrence;
Retrospective Studies;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
2004;47(12):2373-2379
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was aimed to investigate the disease free interval and feasibility of FDG-PET for following up the patients with no evidence of cervical cancer after primary treatment. METHODS: From May, 1998 to February, 2003, 406 patients with no evidence of cervical cancer by FDG-PET were investigated retrospectively. They underwent primary treatment and FDG-PET between 3 to 16 months after treatment. All of them were monitored closely after FDG-PET scanning. RESULTS: Of the 406 patients with no evidence of cervical cancer by FDG-PET after treatment, recurrence was detected in 17 patients. The recurrence sites were lymph nodes (7), lung (6), liver (1), central lesion (1) and others (2). The Mean disease free interval (DFI) in patients with No evidence of disease (NED) was 27 months, DFI with recurrence was 35 months, and the mean DFI in all patients were 28 months (p=0.051). FIGO stage, initial tumor size, status of lymph node metastasis and cell type had no effect on the recurrence rate of NED patients by FDG-PET. Our study also shows high false positive rate and low sensitivity in the conventional imaging and tumor marker. CONCLUSION: The FDG-PET is proved to be a useful imaging study for following up cervical cancer patients after primary treatment. If there is no evidence of disease by the first FDG-PET after primary treatment, we can expect the average disease free interval to be about 28 months. And it is suggested that the patients should undergo the FDG-PET every one or two years to detect possible early recurrence.
