The association of serum CA-125 level and severity of dysmenorrhea with lesion depth in adenomyosis.
- Author:
Seog Hyun JANG
1
;
Tae Soon ANN
;
En Sung OH
;
Jae Hag SIM
;
Ae Lan PAIK
;
Jong Cheon WEON
;
Kang Woo JUNG
;
Yong Pil KIM
Author Information
1. Department of Obstetrics and Gynecology, Pohang Saint Mary's Hospital, Pohang, Korea.
- Publication Type:Original Article
- Keywords:
Adenomyosis;
Dysmenorrhea;
CA-125
- MeSH:
Adenomyosis*;
Animals;
Dysmenorrhea*;
Female;
Humans;
Hysterectomy;
Mice;
Myometrium;
Retrospective Studies
- From:Korean Journal of Obstetrics and Gynecology
2004;47(12):2380-2383
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the association of level of CA-125 and severity of dysmenorrhea with lesion depth in adenomyosis. METHODS: Sixty-eight women who had undergone hysterectomy and were found to have pure adenomyosis on histopathologic examination were reviewed retrospectively. Specimens were stratified according to the degree of adenomyosis penetration into 4 groups: group A consisted of specimens with adenomyosis penetration into myometrium of up to 25%; group B, 26-50%; group C, 51-75%, and group D, >75%. All women were submitted to serum determination of CA-125. Severity of dysmenorrhea was assessed by means of a modification of 10-point verbal rating scale. RESULTS: Each group was not correlated with severity of dysmenorrhea (p=0.7394 Fisher's exact test). The means of serum CA-125 levels was increased corresponding to depth of adenomyosis (p=0.0441 ANOVA test). CONCLUSION: In this study, serum CA-125 level is associated with the depth lesion and severity of dysmenorrhea is not. Therefore, the level of serum CA-125 might be useful indicator in management of adenomyosis before surgery.
