Curative effect of drugs on the prevention of bile duct stones recurrence after ERCP
10.3969/j.issn.1007-1989.2018.05.014
- VernacularTitle:药物预防经内镜逆行胰胆管造影术后结石复发的疗效观察
- Author:
Lei JIN
1
;
Meng DAI
;
Shu-Yu LI
;
Ke CHEN
;
Shan-Shan DUN
;
Juan WU
Author Information
1. 湖北省第三人民医院 消化内科
- Keywords:
bile duct stones;
endoscopic retrograde cholangio-pancreatography;
tauroursodeoxycholic acid;
Danning tablets;
recurrence
- From:
China Journal of Endoscopy
2018;24(5):78-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the curative value of the tauroursodeoxycholic acid (TUDCA) and Danning table (DN) in the prevention of bile duct stones recurrence after ERCP. Methods 210 patients with Choledocholithiasisby ERCP were randomly divided into 3 groups. The patients in the control group were not given any medicine. The patients in the TUDCA group took TUDCA every night. The patients in the DN group took Danning tablets of three times a day. The course of medication and followed up for the patients was 24 months after the operation. All the patients would be examined regularly by Biliary color doppler ultrasound and MRCP. The recurrence rates of Choledocholithiasis, cholesterol saturation index and serum lipid were recorded and compared statistically between the three groups. Results In total, 190 patients completed the treatment and follow-up according to the experimental design. The recurrence rates of the control, TUDCA and DN group were 17.46%(11/63), 6.34% (4/63) and 10.94% (7/64). The recurrence rates in the TUDCA and DN group were significantly lower than those the control group (P < 0.05).The recurrence rate in the TUDCA group was significantly lower than that in the DN group; On the tenth days after the operation, the CSI in the TUDCA were significantly lower than those the control group and the DN group (P < 0.05). There was no statistically significant difference between the DN group and the control group (P > 0.05); To the patients without recurrence, the level of TC, LDL in the TUDCA group were significantly lower than those the control group and and the DN group (P < 0.05). The level of HDL in the TUDCA group were significantly higher than those the control group and and the DN group (P < 0.05). There was no statistically significant difference on the level of HDL between the DN groupand the control group (P > 0.05). Conclusion The application of TUDCA and DN for patients with Choledocholithiasis after ERCP can effectively reduce the recurrence rates, the curative effect of TUDCA more than DN.
