Research progress on influence of intestinal microflora on peripheral immune organs in mice
10.3969/j.issn.1000-484X.2018.06.031
- VernacularTitle:小鼠肠道菌群对外周免疫器官影响的研究进展
- Author:
Huai-Juan XUE
1
;
Long MA
;
Huan QIN
;
Xin-Sheng YAO
Author Information
1. 遵义医学院免疫教研室
- Keywords:
Intestinal flora;
Symbiotic bacteria;
Peripheral immunity;
Immune tolerance;
T cell;
B cell
- From:
Chinese Journal of Immunology
2018;34(6):953-956
- CountryChina
- Language:Chinese
-
Abstract:
The study found that the presence of intestinal microbiota is not only important for the metabolism of essential nutrients in the body, but also plays a key role in the development of the body′s immune system in recent years. Partial microbiota, through natural selection and co-evolution with the host, forms symbiotic relationships with host microbes that are inseparable from host physiology in mice. Symbiotic flora affects the formation of the body′s immune system by affecting innate and adaptive immunity and the development of various regulatory mechanisms. The destruction of the microbial ecosystem in the intestine can lead to the occurrence of many diseases,especially those related to the immune system. Peripheral immune organs always receive a number of immune cells colonized by antigen stimulation. So,the intestinal flora plays an important role in maintaining the function of immune cells. This article will investigates the effects of mouse-related intestinal flora on peripheral immune organ function.
