Alarmins act both an immune and a disease alert
10.3969/j.issn.1000-484X.2018.06.027
- VernacularTitle:警报素既是免疫警报又是疾病警报
- Author:
Zi-Yao QUAN
1
;
Sheng-Gao XIE
;
Tian-Pen CUI
Author Information
1. 武汉市第一医院检验科
- Keywords:
Alarmins;
DAMPs;
Stressorins
- From:
Chinese Journal of Immunology
2018;34(6):935-938,943
- CountryChina
- Language:Chinese
-
Abstract:
Alarmins known as danger associated molecular patterns(DAMPs) are released into the extracellular endogenous bi-ological mediate by white blood cells and epithelial cells when body in a state of tissue injury and inflammation or physiological stress. Immunological and adaptive immune responses are activated and strengthened by chemotaxis and activation of antigen presenting cells(APC). They are closely associated with the disease development and outcome,and have important guiding significance for clinical diagnosis and treatment.
