Regulation of hypoxia-inducible factor α in inflammation-associated diseases mediated by innate immune cells
10.3969/j.issn.1000-484X.2018.06.026
- VernacularTitle:缺氧诱导因子HIF-α在固有免疫细胞参与炎症相关疾病的调控作用
- Author:
Huan-Le LI
1
;
Qing-Qing WANG
;
Yang LIU
Author Information
1. 浙江大学医学院免疫学研究所
- Keywords:
HIF;
Myeloid cells;
Inflammation
- From:
Chinese Journal of Immunology
2018;34(6):929-934
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is a common pathophysiological state especially in the processing inflammatory tissues cells due to hypoxia partial pressure caused by excessive oxygen consumption or insufficient oxygen supply. Hypoxia inducible factor(HIF) that regulates the transcription of downstream target genes in order to cope with the hypoxia environments is induced by various mechanisms in hypoxic state. Studies have demonstrated that HIF-α plays essential roles in the inflammatory response. This paper reviews the recent research that the roles and mechanisms of HIF-α in inflammation-associated diseases mediated by innate immune cells.
