Clinical significance of peripheral blood neutrophil to lymphocyte ratio in patients with 2 type diabetes mellitus complicated acute cerebral infarction
10.3969/j.issn.1000-484X.2018.06.023
- VernacularTitle:2型糖尿病合并急性脑梗死患者外周血中性粒细胞与淋巴细胞比值的临床意义
- Author:
Wen-Bo FAN
1
;
Lin WANG
;
Qiang LI
Author Information
1. 齐河县人民医院内六科
- Keywords:
Diabetes;
Acute cerebral infarction;
Neutrophils to lymphocyte ratio;
Clinical significance
- From:
Chinese Journal of Immunology
2018;34(6):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of peripheral blood neutrophil to lymphocyte ratio in patients with 2 type diabetes mellitus complicated acute cerebral infarction, so as to provide theoretical basis for clinical diagnosis and treatment. Methods:From Jan. 2014 to Dec. 2016 year,136 patients with 2 type diabetes mellitus complicated acute cerebral infarction were selected as research group and 68 diabetic patients undergoing physical examination were selected as the control group. White blood cell count(WBC),neutrophil count(NC),lymphocyte count(LC) and neutrophil to lymphocyte ratio(NLR) were detected and calculated. The role of WBC,NC,LC and NLR in the diagnosis of type 2 diabetes mellitus combined with acute cerebral infarction were evaluated by receiver operating characteristic curve(ROC) and area under the curve(AUC). Results:The levels of WBC,NC and NLR in research group were significantly higher than those of in control group(P＜0. 05),while the level of LC was significantly lower than that of in control group(P＜0. 05). The levels of WBC,NC and NLR in research group increased with the increase of NIHSS score(P＜0. 05),and the level of LC decreased with the increase of NIHSS score(P＜0. 05). The area under the curve of NLR,WBC,NC and LC in diagnosing diabetes combined with acute cerebral infarction were respectively 0. 856,0. 717,0. 685 and 0. 321. The sensitivity were respectively 0. 838,0. 596,0. 517 and 0. 208. The specificity are respectively 0. 868,0. 838,0. 793 and 0. 559. Conclusion:NLR could be used as a marker for the diagnosis of type 2 diabetes with acute cerebral infarction.
