Reseach progress for ECDI-modified autoantigen peptides being used in autoimmune disease
10.3969/j.issn.1000-484X.2018.05.026
- VernacularTitle:ECDI修饰的自身肽在自身免疫病中的研究进展
- Author:
Man-Man ZHU
1
;
Yu-Ming YU
;
Yan-Jun LIU
Author Information
1. 南方医科大学基础医学院免疫学教研室
- Keywords:
ECDI;
Autoimmunity;
Immune tolerance
- From:
Chinese Journal of Immunology
2018;34(5):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Ethylene carbodiimide (ECDI) is a chemical coupling agent,more and more studies have focused on the immune tolerance induced by administration of ethylene carbodiimide (ECDI)-fixed syngeneic splenocytes (Ag-SPs) coupled to peptides or to whole myelin proteins,in order to establish a novel and effective tolerance therapy for autoimmune diseases.The mechanisms and applications of immune tolerance induced by Ag-SPs in several kinds of common autoimmune diseases were summarized,and were compared with their counterparts in the traditional treatment.
