Hp infection and expression of TGF-βR II,IL-6 and TNF-α in patients with chronic atrophic gastritis
10.3969/j.issn.1000-484X.2018.05.022
- VernacularTitle:慢性萎缩性胃炎患者Hp感染与TGF-βRⅡ、IL-6和TNF-α的表达研究
- Author:
Mao-Min HUANG
1
;
Dan-Dan DONG
;
Dan-Dan QI
;
Chen LING
;
Ding-Ding ZHANG
Author Information
1. 遵义医学院免疫教研室
- Keywords:
Hp;
TGF-βRⅡ;
IL-6;
TNF-α;
PCR fluorescence;
Immunohistochemistry
- From:
Chinese Journal of Immunology
2018;34(5):751-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of Helicobacter pylori(Hp) infection in patients with chronic atrophic gastritis (CAG) and the expression of transforming growth factor-β receptorⅡ,interleukin 6 and tumor necrosis factor-α in gastric mucosa.Methods:76 cases of gastroscope biopsy specimens were collected in the CAG patients,the infection of Hp was detected by PCR fluorescence,and immunohistochemical staining was used to determine the expression of TGF-βRⅡ,IL-6 and TNF-α in gastric foveolar epithelium and stromal inflammatory cells.Results:There were significant differences in chronic inflammation between Hp-positive and Hp-negative group (P<0.05).Expression of IL-6 in stromal inflammatory cells was significantly different between Hp-positive and Hp-negative group (P<0.05).Expression of TGF-βRⅡ and TNF-α was not significantly different in two groups(P>0.05).IL-6 expressed instromal inflammatory cells were correlated with chronic inflammation (r=0.249,P=0.03).The degree of intestinal metaplasia and dysplasia were correlated with the atrophic severity respectively(r=0.697,0.366).Conclusion:IL-6 is related to the chronic inflammation in patients with CAG who has Hp infection.The chronic atroplic severity promotes the development of intestinal metaplasia and dysplasia.
