Effect of different glucocorticoid administration routes in treatment of children's secretory otitis media and impacts on immunologic function
10.3969/j.issn.1000-484X.2018.05.020
- VernacularTitle:糖皮质激素治疗儿童分泌性中耳炎中采用鼓室内注射较口服给药可提高疗效及改善免疫功能
- Author:
Yong-Jun FENG
1
;
Ming-Jing WANG
;
Meng-Ying LÜ
;
Qi-Hua DENG
;
Xiang-Ming WU
;
Chun-Rong ZENG
;
Zhi-Ming WU
Author Information
1. 海南医学院第二附属医院耳鼻咽喉头颈外科
- Keywords:
Secretory otitis media;
Glucocorticoid;
Administration route;
Immunologic function;
Audition
- From:
Chinese Journal of Immunology
2018;34(5):741-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of different glucocorticoid administration routes in the treatment of children's secretory otitis media and impacts on immunologic function.Methods:Clinical data of children with secretory otitis media received treatment at our hospital from January 2016 to June 2016 were analyzed.Patients were divided into two groups by different glucocorticoid administration routes,Group A:intratympanic injection;Group B:oral administration.After one week,clinical effects and immunologic functions were tested and compared between the two groups.Results:A total of 87 patients were analyzed,Group A 45 cases,Group B 42 cases.After one week treatment,both of the two groups got significantly improved in audiology indexe (P<0.05),however,these index were more better in Group A when compared with those of Group B(P<0.05).Meanwhile,Group A patients got higher cure rate than that of Group B (91.1%,41/45 vs 73.8%,31/42;X2=4.558,P=0.033).Both of the two groups got significantly improved in CD3+T,CD4+T and CD4/CD8 (P<0.05) and decreased in CD8,IL-4,IFN-γ and IL-4/IFN-γ(P<0.05),but these markers changed more significant in Group A (P<0.05).Group A patients had a lower recurrence rate than Group B patients one year after treatment, the difference was statistically significant (9.76%,4/41 vs 29.03%,9/31;Log-rank X2=4.698,P=0.030).Conclusion:The treatment of children's secretory otitis media,the intratympanic injection of glucocorticoid shows a better effect than that of oral cortico-steroids.
