Distribution of polymorphisms at promoter region of miR-17-92 in Guangxi population and association of its polymorphisms and lymphocytes
10.3969/j.issn.1000-484X.2018.05.016
- VernacularTitle:miR-17-92启动子区多态性在广西人群中分布及与淋巴细胞关系
- Author:
Rong WANG
1
;
Hai-Mei QIN
;
Hua-Tuo HUANG
;
Yu-Lan LU
;
Jing GUO
;
Yan LAN
;
Jun-Li WANG
;
Ye-Sheng WEI
Author Information
1. 右江民族医学院附属医院检验科
- Keywords:
miR-17-92;
Gene cluster;
Polymorphism;
Lymphocytes
- From:
Chinese Journal of Immunology
2018;34(5):723-726,731
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution characteristics of polymorphisms of rs9515692C/T and rs1352743A/G in the promoter region of miR-17-92 gene cluster in Guangxi people and compare them with those of other ethnic groups and explore the association of its polymorphisms and lymphocytes.Methods:The rs9515692C/T and rs1352743A/G of miR-17-92 gene cluster were genotyped by using SNaPshot technique and DNA sequencing.Detection of the number of lymphocytes using flow cytometry.The differences of polymorphisms between groups were analyzed statistically.Results:No significant differences of genotype and allele frequency in the two SNPs was observed between different gender in the Guangxi population(P>0.05).However,there were significant differences in the distribution frequencies of genotype and allele of Europeans,Japanese and Africans in rs9515692C/T and rs1352743A/G (P<0.05).Conclusion:Polymorphisms of rs9515692C/T and rs1352743A/G are different in different people.In addition,rs9515692C/T polymorphism may be associated with the number of B cells.
