Correlation of tyrosine phosphatase-1/2 (SHP-1,SHP-2) with indoleamine 2,3-dioxygenase (IDO) in villi and decidua of early pregnancy

VernacularTitle:早孕绒毛及蜕膜组织中酪氨酸磷酸酶-1/2(SHP-1,SHP-2)与吲哚胺2,3-双加氧酶(IDO)的表达及其相关性
Author: Yan YUAN ¹ ; Yu-Hong WENG ; Shu-Yun ZHAO ; Shi-Xiang LI ; Jun WANG ; Hong-Mei TAN ; Min-Yan YANG ; Guan-You HUANG
Author Information

1. 贵州医科大学附属医院
Keywords: Indoleamine 2; 3-dioxygenase(IDO); Protein tyrosine phosphatase; Villous; Decidua
From: Chinese Journal of Immunology 2018;34(4):513-515,519
CountryChina
Language:Chinese
Abstract: Objective:To explore the correlation of tyrosine phosphatase-1/2 (SHP-1,SHP-2) with indoleamine 2,3-dioxygenase(IDO) in maternal fetal interface.Methods: The expression of SHP-1,SHP-2 and IDO were detected by Western blot method and the relationship of the proteins was analysed,in human chorionic villi and decidua tissues of 30 cases of artificial abortion patients.Results:The expression of SHP-1,SHP-2 were positively correlated withthe expression of IDO in human chorionic villi and de-cidua;the expression of SHP-1,SHP-2 and IDO in decidual tissues were higher than those in the villi.Conclusion: Normal physiological state of pregnancy,SHP-1 and SHP-2 may be involved in the regulation of immune tolerance by positive regulation of IDO expression at maternal fetal interface.